Mathew J. Kluger, PhD

En PEDIATRICS  Vol 66 Nro. 5 Noviembre de 1980

“En conejos adultos se ha estudiado la sobrevida ante la infección de Pasteurella Multocida y ante la  administración de Salicilato de Sodio como antipirético en la mitad de ellos, el resultado fue una  mortandad del 100% en el grupo que recibió Salicilato de Sodio, contra un 29 % en el grupo que desarrolló fiebre”.

Association of high fever and short bacterial excretion after salmonellosis.

Author affiliations: A S el-Radhi, T Rostila, T Vesikari

Abstract:

One hundred and two children with salmonella gastroenteritis were studied for factors affecting the length of convalescent bacterial excretion. There was a significant correlation between degree of fever and duration of excretion: a fever of greater than or equal to 40 degrees C had the shortest and no fever the longest duration of excretion. Fever therefore appears to have a favourable prognostic influence on the length of salmonella excretion.

Acetaminophen: More harm than good for chickenpox?*

Author links open overlay panel. MDTimothy F.Doran^abMDCatherine DeAngelis^abBARosemary A.Baumgardner^abScDE. DavidMellits^ab

https://doi.org/10.1016/S0022-3476(89)80461-5Get rights and content

Study objective To determine whether acetaminophen affects the duration or severity of childhood varicella.

Design: Randomized, double-blind, placebo-controlled trial.

Setting: Office- and hospital-based pediatric practices.

Patients: Seventy-two children between 1 and 12 years of age entered the study. One child was withdrawn because of high fever, and three children did not complete the study; 31 received placebo and 37 received acetaminophen.

Interventions: Acetaminophen, 10 mg/kg/dose, was given at 8 am, 12 pm, 4 pm, and 8 pm for 4 days. Placebo was given to the control group. Itching, appetite, activity, and overall condition were measured for 6 days. The time to last vesicle formation, time to total scabbing, and time to total healing were measured until complete resolution of the exanthem.

Measurements and main results: The following results were better in the placebo group (p<.05): time to total scrabbing 5.6 days (SD 2.5) versus 6.7 days (SD 2.3) in the acetaminophen group, and itching on day 4 in the placebo group (symptom score 2.9 (SD 0.20) vs 2.2 (SD 0.26)). Activity was better in the acetaminophen group on day 2 (3.13 (SD 0.23) vs 2.82 (SD 0.24))

Conclusions: These results provide evidence that acetaminophen does not alleviate symptoms in children with varicella and may prolong illness.

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirusinfected volunteers.

Graham NM, Burrell CJ, Douglas RM, Debelle P, Davies L. J Infect Dis. 1990 Dec;162(6):1277-82.

Source:  Department of Community Medicine, University of Adelaide, South Australia.

Abstract: A double-blind, placebo-controlled trial was conducted to study the effects of over-the-counter analgesic/antipyretic medications on virus shedding, immune response, and clinical status in the common cold. Sixty healthy volunteers were challenged intranasally with rhinovirus type 2 and randomized to one of four treatment arms: aspirin, acetaminophen, ibuprofen, or placebo. Fifty-six volunteers were successfully infected and shed virus on at least 4 days after challenge. Virus shedding, antibody levels, clinical symptoms and signs, and blood leukocyte levels were carefully monitored. Use of aspirin and acetaminophen was associated with suppression of serum neutralizing antibody response (P less than .05 vs. placebo) and increased nasal symptoms and signs (P less than .05 vs. placebo). A concomitant rise in circulating monocytes suggested that the suppression of antibody response may be mediated through drug effects on monocytes and/or mononuclear phagocytes. There were no significant differences in viral shedding among the four groups, but a trend toward longer duration of virus shedding was observed in the aspirin and acetaminophen groups. PMID:2172402

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirusinfected volunteers. Graham NM, Burrell CJ, Douglas RM, Debelle P, Davies L. J Infect Dis. 1990 Dec;162(6):1277-82. Source Department of Community Medicine, University of Adelaide, South Australia. Abstract A double-blind, placebo-controlled trial was conducted to study the effects of over-the-counter analgesic/antipyretic medications on virus shedding, immune response, and clinical status in the common cold. Sixty healthy volunteers were challenged intranasally with rhinovirus type 2 and randomized to one of four treatment arms: aspirin, acetaminophen, ibuprofen, or placebo. Fifty-six volunteers were successfully infected and shed virus on at least 4 days after challenge. Virus shedding, antibody levels, clinical symptoms and signs, and blood leukocyte levels were carefully monitored. Use of aspirin and acetaminophen was associated with suppression of serum neutralizing antibody response (P less than .05 vs. placebo) and increased nasal symptoms and signs (P less than .05 vs. placebo). A concomitant rise in circulating monocytes suggested that the suppression of antibody response may be mediated through drug effects on monocytes and/or mononuclear phagocytes. There were no significant differences in viral shedding among the four groups, but a trend toward longer duration of virus shedding was observed in the aspirin and acetaminophen groups. PMID:2172402